[ghaff]

I'd argue that question, the way it's phrased, is very revealing the advance of tech and the things enabled by tech don't begin and end with smartphone apps. There's a pretty strong social/web/app mindset to the SV lens today and it causes a lot of people to undervalue and overlook what's happening elsewhere. For example, as other have mentioned, biotech/pharma is huge in places like Cambridge and is barely represented in SV.

[onewaystreet]

I used the term "app" but I really meant company. But the important term in the question is "blockbuster". If people are undervaluing and overlooking what's happening elsewhere it's because those things aren't blockbusters. Biotech/pharma companies have been pretty disappointing in terms of blockbuster discoveries. Maybe CRISPR will change that.