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Every prime minister has their "Suez":

David Cameron: losing the EU referendum

Gordon Brown: The financial crisis

Tony Blair: Iraq

John Major: Black Wednesday; Tory party "sleaze"

Margaret Thatcher: The poll tax

James Callaghan: The Winter of Discontent

… etc.

[danieltillett]

All political lives, unless they are cut off in midstream at a happy juncture, end in failure, because that is the nature of politics and of human affairs.

Enoch Powell