This study is attempting to show that psilocybin is effective in treating depression, not effective in inducing a 'trip'. For patients who have never experimented with psychotropics, there may be a placebo effect when they are told they are given a psychotropic substance. While I agree that psilocybin and other similar substances can induce powerful mental states unreachable by other means, it does not follow that there exists a clinical path by which these drug-induced states can be used to treat depression in a reliable way.