[austinjp]

While cumulative effects no doubt contribute to tissue changes, those changes aren't necessarily going to be for the worse. Leg bones and cartilage adapt positively to the light impact and weight-bearing of walking (for most people, most of the time, in most circumstances). In fact a lack of upright weight bearing in 20s and 30s may contribute to the development of osteoporosis and cartilage thinning.

Your mileage may vary (apologies for the pun) but if you can, walk.