[toothbrush]

Or, John was set upon going to the movies tonight, but his friend refused to join him.

Admittedly, that sounds a bit old-fashioned.

[jdmichal]

Honestly any use of upon sounds old-fashioned. It's generally been replaced by on, except in a few contexts by up. Even Google defines it as "a more formal term for on".

[ghaff]

Set on is probably a bit more natural in that context although I'm not sure either is particularly common phraseology.