You misunderstood the problem. The problem isn't that programmers can't write loops that are easy to optimize. It's rather that, in practice, they don't write loops that are easy to optimize. That's ultimately a problem with the C language.
The easiest way to write the loop is the way that is hard to optimize. This is a fact that is beyond dispute: empirically, programmers use int to index over arrays in for loops without writing asserts. That is in fact a problem with the language.
When designing tools for use by humans, you need to accept the fact that humans, with all our failings, will be the ones using the tools. So tools should be made resilient against typical ways in which humans fail.
We've been paying for shortcomings in C's design for decades with bugs and security failures that simply don't happen in other languages. That you refuse to see this is baffling to me.
When a common idiom becomes the wrong way to do something, someone messed up pretty badly (and preexisting idiom at that).
Arguably the designers of amd64 should have caught this before releasing the ABI or the language design could have been specified so this wasn't an issue in the first place.
Can assert() actually function this way? Can you use assert to tell the optimizer it can assume something is true?
I've noticed that memcpy(x, y, 4) on x86 can generate very efficient code (register move), but on ARM it expands to something much more verbose because the addresses might not be aligned.
Could this effectively function as a way of promising to the compiler that the addresses are aligned?
Interesting! This assert_and_assume() seems strictly better than vanilla assert() for any predicates that don't have side effects. But I guess you have to be sure that the compiler is able to deduce that there aren't side effects and feels comfortable optimizing away the predicate in release mode.
Recent compilers support some extensions that can do it better. GCC and CLang use __builtin_assume_aligned(), and ICC uses __assume_aligned() (haven't tested the synonym).