[phren0logy]

It's a cool visualization, but their cutoff line is labeled "worth it." To really justify that, they need more information. Thankfully the bubbles are broken down by specific health claim (so that some supplements have several bubbles for their effect on different conditions), but to determine "worth it," they need to include:

1. Some sort of way to account for type and frequency of side effects. For example if everyone who takes the supplement gets an intolerably bad taste in their mouth, that's a mild but prevalent side effect. If one person in 100,000 who takes the supplement dies, that's a comparatively rare but very serious side effect. This factors heavily into the "worth it" determination, because risk is a consideration.

2. Cost. If a supplement has a mild beneficial effect but costs $1,000 a month, I'm not sure most people would say it's "worth it."

3. Strength of effect. A statistically significant improvement is not necessarily clinically significant. For example, with a large sample a 1% decrease in LDL cholesterol may be statistically significant, but it is not clinically significant.

Those factors would help a person determine the pros and cons effectively. What is "worth it" varies considerably from person to person.