[meowface]

That's a major overgeneralization. For one, many people with ADHD who take Adderall for years eventually have to stop taking the drug because their dopamine receptors have downregulated so much and the medication no longer works.

[cel1ne]

I'm not talking about downregulating receptor response, but entire areas of the brain like the insula and parts of the frontostriatal circuit.

[meowface]

Ah, I see. Sorry for the misunderstanding.

Based on the literature, it seems like a probable explanation.