Not in Mountain View & Sunnyvale. The peninsula curves around at the bottom, so north/south routes like 101, 82 (El Camino), and 280 go mostly east/west, with 85 branching off as a north/south spur. The "north" side of 101 is the side closest to the Bay, where Google is. Throws a lot of visitors for a loop.
Through the peninsula, especially in mountain view, it runs from southeast to northwest, north is towards the bay; south is towards the mountains. ca-85 is much closer to north/south through mountain view.
Yeah, San Carlos air traffic controllers get pissy when you announce northbound over the 101 and you're really flying due west, with the sun in your face even.