[webjprgm]

When I worked at Apple we used a native Mac issue tracker. It was much nicer than anything I've used before or since. I hate having to click-refresh-back-forward in a browser window, whereas a native client can have multiple windows, one for my assigned list, one for a search I did, then I minimize that search window and make a new window for a new search, then I cmd-H to hide the whole app without also hiding my browser.

At my current company we have an in-house project/issue tracker system which isn't quite as good as Apple's IMHO but very customized to this company's workflow. For my at-home consulting projects I try various web apps, most recently Mantis.