DF badly needs that for the key combinations. They're complete nonsense, and in all the time I've spent playing, I've always needed a cheat-sheet for even the things I didn't do all that rarely.
But I'm guessing that's not trivial to implement if you haven't already started doing it that way, and for something like Dwarf Fortress, it would probably be a lot of effort for not a significant amount of result - after all, everyone's already got their cheat sheet...
You may want to take a look at Gnomoria (http://gnomoria.com), which is basically "DF clone with sensible voxel graphics". For example: http://images.akamai.steamusercontent.com/ugc/45067176442464...
It's not a scriptable interface, but it is much saner than DF's, with a limited set of consistent hotkeys/toolbars/panels.