React generally requires more than just a wrapper, since its virtual DOM is populated in a highly controlled manner that libraries need to follow. But you can try.
Actually it's pretty trivial. You can always just have your render function be just a static div, set a ref to the div, and do setup in componentDidMount and updates in componentWillUpdate. Since the render function will always return a trivially identical subtree, it will never change that DOM node. Of course, if your component moves in the HTML hierarchy, your animation may restart, but that's unlikely in most use cases.