Doesn't matter. It's the "reflections on trusting trust" kind of thing - we, our parents, grandparents, etc. form a chain; some runtime modifications to replication mechanism could propagate forward indefinitely, without changing the DNA in the process.
But, it is like commenting out regions in code. You are factually right, in that there is no editing of the DNA sequence i.e. no mutations. But this phenomenon exerts a similar end effect.