[jodrellblank]

There is literally nothing objectively "meaningful" to do that we know of. At all. Anywhere. Ever.

The concepts of "meaning" and "meaningful" come from the human mind, it's subjective. Anything can be 'meaningful' to someone and not to someone else.

The point is not to make other people sad when you're gone, the point is to make other people (and yourself) happier while you're alive.

[alashley]

Agreed, and there's no guarantee that pursuing what we deem to be meaningful at the expense of interpersonal relationships will leave a mark on humanity. As a matter of fact, a lot of great men and women are/were the product of investments (not necessarily monetary) from their parents, teachers, friends, and family.