[zmmmmm]

This seems like potentially an incredibly important breakthrough with a perplexingly weird title. Different brain regions? Different to what? From reading the study, the novelty is not about the "difference" of the brain regions, but the fact that fungal infection is found in AD patients at all. The controls had no infection, not different infections in their brains.

I'm curious if the title makes sense to people in the field or is this weird to them too?

[soneca]

As a layman, i understood the title correctly I guess. That there were fungi not just on one spot, but different (ie several) regions.

[Myrmornis]

But that would be bad English. I wouldn't expect the Nature editors to let such bad English slip through in an important title, but I admit it is frustratingly common to see people not caring too much about that sort of thing.

I had the same concern as GP. I don't understand the title; the controls seem not to have fungi in their brain, which had always been my assumption about, for example, my brain.

[zmmmmm]

After reflecting I am wondering if this is a result of the natural tendency of scientists to avoid any hint of overstating their work. Were the fungal infections all in the same region or by the same fungus it'd be absolutely shocking. It'd be a "cold fusion" level revolution for the field - and a "cold fusion" level embarrassment for them if they are wrong. So they are extremely keen to put up front that the picture is not nearly so clear as that.

There is also a tendency when scientists are extremely confident they have found something incredibly important to understate it. I always think of the Watson and Crick "It has not escaped our notice ..." statement in this context.

This is all based on guesswork though, so that's why I'm curious about what people in the field think.

[zmmmmm]

So, interpreting "different" as "multiple"? Seems unnecessary to use an ambiguous word. And then an ambiguous word that is not actually the main point of the study.

[nonbel]

They meant multiple, the authors are from Spain. I'm not sure why an editor wouldn't try to alter the title though, perhaps they are also not native english speakers.