[macournoyer_]

Talker is more extensible, we're focusing on API and plugins http://talker.tenderapp.com/faqs/api, has inline feed notification for eg.: github commits, twitter search results, tickets updates in the chat room. And a lot more to come.

Talker also has a free version (4 concurrent users) https://talkerapp.com/signup/free

[bentlegen]

I'm really excited about applications that provide JavaScript-based APIs.

DabbleDB is another app that does this: http://dabbledb.com/help/guides/jsapi/