[compbio]

Web design and development is also an art. Good artists look beyond business value.

You actually should bend over backwards to cater to as many users as possible, especially if you are getting paid to build websites for users.

Some countries require sites to be accessible to the disabled. If you design sites for the US government, they should also be accessible to 0.1% of blind or no-script users.

Sure, IE6 as a baseline is very progressive, but it is certainly doable. Less so, if you start with an inaccessible website and catering to as many users as possible is an annoying time-consuming afterthought.

If you can not muster an accessible progressive enhanced website, then you can not muster a js-only ARIA compliant website either. Your only hope is to make something profitable. That's being a marketeer or business man with a little HTML skills, not being a solid web dev.