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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
492 points by gmays 5 hours ago | 133 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
171 points by ibobev 2 hours ago | 118 comments
3.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
183 points by marc__1 1 day ago | 118 comments
4.
How to setup a local coding agent on macOS (ikyle.me)
132 points by kkm 3 hours ago | 45 comments
5.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
114 points by iweczek 3 hours ago | 43 comments
6.
Slightly reducing the sloppiness of AI generated front end (envs.net)
135 points by FergusArgyll 6 hours ago | 94 comments
7.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
24 points by arcb 3 hours ago | 9 comments
8.
A PDF that changes based on how its read (sgaud.com)
93 points by SarthakGaud 4 hours ago | 51 comments
9.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
84 points by ibobev 5 hours ago | 50 comments
10.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
51 points by jtlebigot 6 hours ago | 14 comments
11.
A dumpster arrived behind my university's library (yalereview.org)
138 points by mooreds 6 hours ago | 116 comments
12.
There Is Life Before Main in Rust (grack.com)
49 points by mmastrac 1 day ago | 13 comments
13.
Cosmodial Sky Atlas (killedbyapixel.github.io)
17 points by memalign 2 hours ago | 1 comments
14.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
152 points by speckx 2 hours ago | 130 comments
15.
Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
67 points by bookofjoe 3 hours ago | 49 comments
16.
Maxproof (arxiv.org)
119 points by ilreb 8 hours ago | 10 comments
17.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1421 points by jjfoooo4 21 hours ago | 446 comments
18.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
34 points by datafreak_ 5 hours ago | 9 comments
19.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 7 hours ago
20.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
288 points by FergusArgyll 6 hours ago | 189 comments
21.
WASI 0.3 (bytecodealliance.org)
206 points by mavdol04 7 hours ago | 82 comments
22.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
100 points by xngbuilds 4 hours ago | 31 comments
23.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
52 points by _____k 8 hours ago | 5 comments
24.
A jacket that harvests drinking water from the air (news.utexas.edu)
153 points by ilreb 21 hours ago | 96 comments
25.
New privacy frontier: Europe eyes crackdown on smart glasses (politico.com)
71 points by 1vuio0pswjnm7 4 hours ago | 55 comments
26.
Kimi K2.7-Code: open-source coding model with better token efficiency (huggingface.co)
375 points by nekofneko 10 hours ago | 199 comments
27.
Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
705 points by sam_bristow 20 hours ago | 238 comments
28.
You can power on a Mac remotely (jeffgeerling.com)
18 points by speckx 5 hours ago | 8 comments
29.
Show HN: Script to bulk delete Claude chats from the web UI (github.com)
47 points by ML0037 5 hours ago | 17 comments
30.
Vinyl succumbs to Loudness War: more than just collateral damage (2025) (magicvinyldigital.net)
141 points by sneela 6 days ago | 216 comments