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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
561 points by gmays 6 hours ago | 152 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
212 points by ibobev 4 hours ago | 151 comments
3.
Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org)
47 points by DASD 2 hours ago | 18 comments
4.
How to setup a local coding agent on macOS (ikyle.me)
160 points by kkm 4 hours ago | 55 comments
5.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
219 points by marc__1 1 day ago | 145 comments
6.
Mmorpg World of ClaudeCraft, vibe coded with Fable 5 (worldofclaudecraft.com)
30 points by beatthatflight 1 hour ago | 12 comments
7.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
136 points by iweczek 4 hours ago | 63 comments
8.
Palantir loses legal challenge against Swiss investigative magazine (ft.com)
53 points by sschueller 1 hour ago | 7 comments
9.
Can I Buy Your KV Cache? (arxiv.org)
10 points by MediaSquirrel 1 hour ago | 7 comments
10.
Slightly reducing the sloppiness of AI generated front end (envs.net)
145 points by FergusArgyll 7 hours ago | 101 comments
11.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
28 points by arcb 4 hours ago | 15 comments
12.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
89 points by ibobev 6 hours ago | 52 comments
13.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
63 points by jtlebigot 7 hours ago | 20 comments
14.
Cosmodial Sky Atlas (killedbyapixel.github.io)
22 points by memalign 3 hours ago | 2 comments
15.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
203 points by speckx 4 hours ago | 185 comments
16.
A PDF that changes based on how its read (sgaud.com)
104 points by SarthakGaud 5 hours ago | 56 comments
17.
There Is Life Before Main in Rust (grack.com)
57 points by mmastrac 1 day ago | 13 comments
18.
Maxproof (arxiv.org)
122 points by ilreb 9 hours ago | 10 comments
19.
A dumpster arrived behind my university's library (yalereview.org)
143 points by mooreds 7 hours ago | 125 comments
20.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1447 points by jjfoooo4 22 hours ago | 452 comments
21.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 8 hours ago
22.
You can power on a Mac remotely (jeffgeerling.com)
33 points by speckx 6 hours ago | 21 comments
23.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
298 points by FergusArgyll 7 hours ago | 195 comments
24.
WASI 0.3 (bytecodealliance.org)
213 points by mavdol04 8 hours ago | 83 comments
25.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
36 points by datafreak_ 6 hours ago | 12 comments
26.
Most Beautiful Will Ever Made (1936) (paperspast.natlib.govt.nz)
12 points by cf100clunk 3 hours ago | 3 comments
27.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
56 points by _____k 9 hours ago | 7 comments
28.
EV demand up 50% in France and Germany since Iran war (reuters.com)
47 points by a_paddy 3 hours ago | 12 comments
29.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
117 points by xngbuilds 5 hours ago | 33 comments
30.
Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
710 points by sam_bristow 21 hours ago | 241 comments