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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
450 points by gmays 5 hours ago | 125 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
150 points by ibobev 2 hours ago | 103 comments
3.
How to setup a local coding agent on macOS (ikyle.me)
104 points by kkm 2 hours ago | 41 comments
4.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
159 points by marc__1 23 hours ago | 102 comments
5.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
88 points by iweczek 3 hours ago | 40 comments
6.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
90 points by xngbuilds 3 hours ago | 26 comments
7.
A PDF that changes based on how its read (sgaud.com)
83 points by SarthakGaud 3 hours ago | 43 comments
8.
Slightly reducing the sloppiness of AI generated front end (envs.net)
128 points by FergusArgyll 5 hours ago | 85 comments
9.
Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
52 points by bookofjoe 3 hours ago | 37 comments
10.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
21 points by arcb 3 hours ago | 8 comments
11.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
78 points by ibobev 4 hours ago | 46 comments
12.
AI agent bankrupted their operator while trying to scan DN42 (lantian.pub)
1341 points by xiaoyu2006 15 hours ago | 482 comments
13.
A dumpster arrived behind my university's library (yalereview.org)
128 points by mooreds 5 hours ago | 112 comments
14.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
46 points by jtlebigot 5 hours ago | 13 comments
15.
There Is Life Before Main in Rust (grack.com)
43 points by mmastrac 1 day ago | 12 comments
16.
Maxproof (arxiv.org)
118 points by ilreb 8 hours ago | 9 comments
17.
Cosmodial Sky Atlas (killedbyapixel.github.io)
13 points by memalign 2 hours ago | 1 comments
18.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1406 points by jjfoooo4 21 hours ago | 443 comments
19.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 7 hours ago
20.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
281 points by FergusArgyll 5 hours ago | 183 comments
21.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
125 points by speckx 2 hours ago | 111 comments
22.
WASI 0.3 (bytecodealliance.org)
202 points by mavdol04 6 hours ago | 82 comments
23.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
30 points by datafreak_ 4 hours ago | 8 comments
24.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
49 points by _____k 7 hours ago | 5 comments
25.
Kimi K2.7-Code: open-source coding model with better token efficiency (huggingface.co)
360 points by nekofneko 9 hours ago | 195 comments
26.
A jacket that harvests drinking water from the air (news.utexas.edu)
147 points by ilreb 21 hours ago | 93 comments
27.
New privacy frontier: Europe eyes crackdown on smart glasses (politico.com)
63 points by 1vuio0pswjnm7 3 hours ago | 46 comments
28.
Show HN: Script to bulk delete Claude chats from the web UI (github.com)
46 points by ML0037 5 hours ago | 16 comments
29.
Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
697 points by sam_bristow 19 hours ago | 232 comments
30.
Vinyl succumbs to Loudness War: more than just collateral damage (2025) (magicvinyldigital.net)
138 points by sneela 6 days ago | 216 comments