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1. CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
581 points by gmays 6 hours ago | 154 comments
2. Swift at Apple: Migrating the TrueType hinting interpreter (swift.org)
62 points by DASD 2 hours ago | 22 comments
3. Mmorpg World of ClaudeCraft, vibe coded with Fable 5 (worldofclaudecraft.com)
35 points by beatthatflight 1 hour ago | 19 comments
4. How to setup a local coding agent on macOS (ikyle.me)
169 points by kkm 4 hours ago | 56 comments
5. Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
227 points by marc__1 1 day ago | 151 comments
6. Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
146 points by iweczek 5 hours ago | 63 comments
7. Palantir loses legal challenge against Swiss investigative magazine (ft.com)
76 points by sschueller 1 hour ago | 12 comments
8. Slightly reducing the sloppiness of AI generated front end (envs.net)
148 points by FergusArgyll 7 hours ago | 102 comments
9. Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
29 points by arcb 5 hours ago | 16 comments
10. Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
63 points by jtlebigot 7 hours ago | 21 comments
11. Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
90 points by ibobev 6 hours ago | 53 comments
12. "Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
213 points by speckx 4 hours ago | 190 comments
13. A PDF that changes based on how its read (sgaud.com)
106 points by SarthakGaud 5 hours ago | 56 comments
14. I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
224 points by ibobev 4 hours ago | 158 comments
15. Cosmodial Sky Atlas (killedbyapixel.github.io)
22 points by memalign 3 hours ago | 2 comments
16. There Is Life Before Main in Rust (grack.com)
60 points by mmastrac 1 day ago | 14 comments
17. Maxproof (arxiv.org)
123 points by ilreb 10 hours ago | 10 comments
18. If you are asking for human attention, demonstrate human effort (tombedor.dev)
1455 points by jjfoooo4 23 hours ago | 453 comments
19. Most Beautiful Will Ever Made (1936) (paperspast.natlib.govt.nz)
17 points by cf100clunk 3 hours ago | 6 comments
20. EV demand up 50% in France and Germany since Iran war (reuters.com)
56 points by a_paddy 3 hours ago | 17 comments
21. A dumpster arrived behind my university's library (yalereview.org)
143 points by mooreds 7 hours ago | 128 comments
22. You can power on a Mac remotely (jeffgeerling.com)
36 points by speckx 6 hours ago | 24 comments
23. Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 8 hours ago
24. WASI 0.3 (bytecodealliance.org)
215 points by mavdol04 8 hours ago | 84 comments
25. Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
36 points by datafreak_ 6 hours ago | 12 comments
26. A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
299 points by FergusArgyll 7 hours ago | 198 comments
27. Looking Forward to Postgres 19: It's About Time (pgedge.com)
123 points by xngbuilds 5 hours ago | 36 comments
28. Can I Buy Your KV Cache? (arxiv.org)
15 points by MediaSquirrel 1 hour ago | 10 comments
29. Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
58 points by _____k 9 hours ago | 9 comments
30. Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
713 points by sam_bristow 21 hours ago | 241 comments