For almost a decade the SENS Research Foundation has helped to fund research by various groups on the allotopic expression of mitochondrial genes, a way to both cure mitochondrial disease and, more importantly, prevent mitochondrial DNA damage from contributing to the aging process. Allotopic expression works by creating backup copies of important mitochondrial genes in the cell nucleus, altered so that the resulting proteins can make their way back to the mitochondria where they are needed.

Finally the long awaited peer reviewed paper showing the transfer of Stable nuclear expression of ATP8 and ATP6 genes has been published and is a long anticipated proof of concept of one of the key concepts of the SENS repair of aging approaches. We are reaching the point where hacking human biology and aging is becoming a reality.