FYI, I've had some really bad problems crop up when using sym links to deploy php releases (php selectively using files from older versions), and I've encountered others who've had similar problems. I don't know if it's been fixed in newer versions, but problems include the realpath cache not getting properly reset (and clearstatcache() wouldn't let you clear the realpath cache until 5.3).
Here's someone else who had this problem, although he claims cycling Apache would fix it (it didn't for me):
Simply don't store user-created content (images) in a folder in your main site, that doesn't scale anyway. Put pictures in pic.mysite.com or something like that (you can map an S3 bucket to that if you like).
Here's someone else who had this problem, although he claims cycling Apache would fix it (it didn't for me):
http://www.mikebrittain.com/blog/2009/05/12/case-against-usi...