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1.
CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
505 points by gmays 5 hours ago | 134 comments
2.
I Am Not a Reverse Centaur (blog.miguelgrinberg.com)
181 points by ibobev 3 hours ago | 129 comments
3.
Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org)
24 points by DASD 1 hour ago | 6 comments
4.
How to setup a local coding agent on macOS (ikyle.me)
139 points by kkm 3 hours ago | 46 comments
5.
Malware developers added nuclear and biological weapons text to to their spyware (twitter.com)
191 points by marc__1 1 day ago | 130 comments
6.
Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
121 points by iweczek 4 hours ago | 49 comments
7.
Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
26 points by arcb 4 hours ago | 9 comments
8.
"Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
174 points by speckx 3 hours ago | 147 comments
9.
Slightly reducing the sloppiness of AI generated front end (envs.net)
138 points by FergusArgyll 6 hours ago | 97 comments
10.
A PDF that changes based on how its read (sgaud.com)
94 points by SarthakGaud 4 hours ago | 53 comments
11.
Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
85 points by ibobev 5 hours ago | 50 comments
12.
Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr)
55 points by jtlebigot 6 hours ago | 14 comments
13.
Cosmodial Sky Atlas (killedbyapixel.github.io)
19 points by memalign 2 hours ago | 1 comments
14.
A dumpster arrived behind my university's library (yalereview.org)
140 points by mooreds 6 hours ago | 117 comments
15.
There Is Life Before Main in Rust (grack.com)
52 points by mmastrac 1 day ago | 13 comments
16.
Can I Buy Your KV Cache? (arxiv.org)
3 points by MediaSquirrel 56 minutes ago | 1 comments
17.
Maxproof (arxiv.org)
120 points by ilreb 9 hours ago | 10 comments
18.
If you are asking for human attention, demonstrate human effort (tombedor.dev)
1427 points by jjfoooo4 22 hours ago | 446 comments
19.
Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
35 points by datafreak_ 5 hours ago | 10 comments
20.
A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net)
291 points by FergusArgyll 6 hours ago | 190 comments
21.
Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
1 points by augustschen 7 hours ago
22.
Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
72 points by bookofjoe 4 hours ago | 55 comments
23.
WASI 0.3 (bytecodealliance.org)
209 points by mavdol04 7 hours ago | 82 comments
24.
Looking Forward to Postgres 19: It's About Time (pgedge.com)
105 points by xngbuilds 4 hours ago | 32 comments
25.
Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
52 points by _____k 8 hours ago | 5 comments
26.
A jacket that harvests drinking water from the air (news.utexas.edu)
153 points by ilreb 22 hours ago | 96 comments
27.
Kimi K2.7-Code: open-source coding model with better token efficiency (huggingface.co)
383 points by nekofneko 10 hours ago | 199 comments
28.
You can power on a Mac remotely (jeffgeerling.com)
24 points by speckx 5 hours ago | 10 comments
29.
Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
707 points by sam_bristow 20 hours ago | 239 comments
30.
Palantir loses legal challenge against Swiss investigative magazine (ft.com)
9 points by sschueller 31 minutes ago | 2 comments